Circadian rhythms regulate various physiological functions such as metabolism and glycan structures; however, their dynamics and associations with diseases are not yet fully understood. Here, we introduce a paper published in the Journal of Proteome Research titled “Time-of-Day Differences in the Plasma N-Glycome of Normal and Obese Mice and the Effects of Dapagliflozin Administered in the Morning or at Night.” In this study, our product BlotGlyco^™ (Glycoblotting method) was used to comprehensively analyze time-of-day variations in plasma N-glycans of normal and obese mice. Additionally, the effects of the diabetes drug dapagliflozin were evaluated. The results demonstrated that N-glycans fluctuate in a time-dependent manner, and dapagliflozin administration shifted the plasma N-glycan profile of obese mice closer to that of normal mice. The influence of sampling time on glycan analysis was also clarified, highlighting the importance of carefully timing sample collection. This study deepens the understanding of glycan dynamics and provides valuable insights for elucidating the mechanisms of diabetes therapeutics and for biomarker discovery.

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We're hosting an S-Bio webinar in September!!
Recent advances in Organoid Production and Drug Discovery

On Thursday, September 10, at 4:00 p.m., we will host the S-Bio Webinar titled “Recent Advances in Organoid Production and Drug Discovery.” In the first half of this webinar, Hideya Sakaguchi M.D., Ph.D. of the National Center for Child Health and Development-a leading figure in organoid research in Japan-will deliver a presentation on the development of neural organoids based on developmental biology and their potential applications in drug discovery. In the second half, we will welcome Thomas Mitchell, CEO, and Prof. Ernst Wolvetang, CSO, from The Organoid Company in the Netherlands-an enterprise with cutting-edge organoid automation technology-to introduce fully automated, high-throughput organoid production technology for toxicity testing. We sincerely look forward to your participation.

Report on our Participation at Exhibition and Luncheon Seminar at the 53rd Annual Meeting of the Japanese Society of Toxicology

At the 53rd Annual Meeting of the Japanese Society of Toxicology (July 1-3), held at Grand Cube Osaka, we exhibited products related to our Micro Physiological Systems (MPS)-which replicate the functions of human organs and tissues on a chip-as well as our 3D cell culture products, which cultivate cells in a three-dimensional environment that closely mimics the in vivo environment. We would like to express our sincere gratitude to the many attendees who visited our booth throughout the three-day event. In particular, we hosted a luncheon seminar co-organized by the four companies comprising the MPS Team of the Consortium for Safety Assessment of Human iPS Cell Applications (CSAHi). The seminar was titled “The Future of Safety Assessment Pioneered by MPS.” The event was so well-attended that some attendees had to stand, reaffirming the high level of interest and attention the industry as a whole has for safety evaluation utilizing these “MPS” and “3D cell culture” technologies. We will continue to be actively engaged in information dissemination and exhibition activities to contribute to the promotion and development of next-generation technologies that enable the evaluation of drug safety under conditions closer to the human body, without relying on animal testing. We will announce details regarding our participation in the next exhibitions as soon as they are finalized. We sincerely look forward to seeing you there.