News from the S-BIO Business Division,
Sumitomo Bakelite Co., Ltd.

The mechanisms underlying human embryo implantation remain largely unclear due to ethical and technical limitations, particularly concerning the three-dimensional architecture of the endometrial tissue and its interactions with the embryo. Here, we introduce a paper published in Science Advances titled “Modeling embryo-endometrial interface recapitulating human embryo implantation”. In this study, researchers developed apical-out endometrial organoids (AO-EMO) model that mimics the in vivo structure and hormonal responsiveness of the human endometrium. The AO-EMO feature an outward-facing apical surface, dense stromal cells, and a self-assembled endothelial network, with enhanced maturation and secretion functions upon hormonal stimulation. By coculturing these AO-EMO with human embryonic stem cell-derived blastoids, the team established a "feto-maternal assembloid" model that faithfully reproduces key implantation stages such as apposition, adhesion, and invasion. Using human blastocysts, they confirmed invasion and fusion of syncytial cells and endometrial stromal cells within this model, enabling detailed investigations of cellular fusion and interactions during implantation. The STEMFULL^™ system was employed during single-cell RNA sequencing sample preparation to minimize cell loss and adhesion, thereby supporting the acquisition of high-quality data. This model provides a novel platform to dissect the complex biochemical and physical interactions at the embryo-endometrial interface, offering valuable insights for advancing reproductive medicine.

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Exhibiting and Presenting at MPS World Summit 2026

We are pleased to announce that we will be exhibiting and presenting a poster at the "MPS World Summit 2026," held from May 26 to May 29 in Washington, D.C., USA.
Our poster presentation will showcase an innovative application using the BioStellar^™ Plate and MyoFlex^™ Plate. By integrating 3D cardiac tissues with liver models, we have developed a coupled co-culture system that enables cardiotoxicity assessment considering hepatic drug metabolism.
Our platform's unique features-low drug adsorption and removable pillars-address critical challenges in current MPS workflows, providing more accurate and physiological data for drug discovery.

I'm Aiko Mizuno from the S-Bio Business Division. How was everyone's Golden Week? I went back to my family home in Osaka, watched movies, and took a refreshing walk around Katsuo-ji Temple in Minoh. On the other hand, recently I've become concerned about my rounded shoulders and hunched posture, so I'm making a habit of loosening up my body using bath towels and a stretch pole. May can be a tough time right after the holidays, but let's get through it comfortably by incorporating refreshment methods that suit each of us!