Electromagnetic fields are invisible to the naked eye, but they are generated from sources such as power lines and household appliances, and are constantly present around us. The World Health Organization (WHO) evaluated the potential health risks of electromagnetic fields in the frequency range of 1 Hz to 100 kHz in 2007 and compiled the findings as environmental health criteria.
Additionally, in 2023, the Environmental Safety Division of the Environmental Health Department of the Ministry of the Environment in Japan revised a booklet titled "Electromagnetic Fields Around Us," which introduces basic knowledge about electromagnetic fields and their health effects.
Here, we will introduce an application note we issued based on paper “Stimulus effects of extremely low-frequency electric field exposure on calcium oscillations in a human cortical spheroid” published in Bio Electro Magnetics.
To accurately evaluate the biological effects of electromagnetic fields (EMFs) at the cellular level, it is important to use biological samples that closely resemble human organs in experimental studies.
However, previous studies have not conducted EMF exposure experiments using cultured neuronal networks derived from the human brain and central nervous system. The authors cultured iPSC-derived neural cells using PrimeSurface^™ Plate 96U to produce human cerebral cortical spheroids (hCSs). These hCSs, composed of neuronal cells derived from human induced pluripotent stem cells (hiPSCs) and possessing three-dimensional neuronal network structures, were applied to EMF exposure experiments. The suitability of hCSs for evaluating stimulus effects, which serve as the foundation of international EMF exposure guidelines, was investigated. The hCSs produced using PrimeSurface^™ were demonstrated to mimic three-dimensional neuronal network structures in vivo and were deemed appropriate for assessing neuronal stimulation responses in vitro.
For detailed application information, click Read More.

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Report on Exhibition at the 3rd Forum of Japan MPS Initiative

On Wednesday, January 21, we exhibited at the "3rd Forum of Japan MPS Initiative (co-hosted by CSAHi-MPS)" held at Tower Hall Funabori. On that day, in addition to our multi-organ MPS product, the BioStellar^™ Plate, we showcased and conducted hands-on sessions for the dedicated stirrer device "BioStellar^™ Plate Stirrer-Dock," which began accepting orders last December.
A total of 15 participants from 13 companies joined the hands-on sessions, where our researchers directly explained the features and operation methods of the products. We hope our products will be of assistance to the research of all visitors. Thank you very much for taking the time out of your busy schedules to visit our booth.