News from the S-BIO Business Division, Sumitomo Bakelite Co., Ltd.
Introduction of Research Papers using PrimeSurface™
The tumor suppressor gene FBXW7 inhibits cancer stem cell properties, and inhibition of KCa1.1 (calcium-activated potassium channel) is involved in its function; however, the detailed transcriptional regulation of FBXW7 and intracellular signaling induced by KCa1.1 inhibition remain unclear.
Here, we introduce a paper published in the International Journal of Molecular Sciences titled "Transcriptional Up-Regulation of FBXW7 by KCa1.1 K+ Channel Inhibition through the Nrf2 Signaling Pathway in Human Prostate Cancer LNCaP Cell Spheroid Model."
This study used a 3D spheroid model of human prostate cancer LNCaP cells and revealed that KCa1.1 inhibition promotes the transcriptional activation of the tumor suppressor gene FBXW7 via the Akt-Nrf2 signaling pathway.
PrimeSurface® 96 U plate was used to form 3D spheroids for gene and protein expression analyses and other assays showing significantly increased FBXW7 expression and reduced Nrf2 nuclear translocation after KCa1.1 inhibitor PAX treatment. Furthermore, siRNA-mediated suppression of FBXW7 expression was observed.
These results suggested that FBXW7 plays a crucial role in transcriptional regulation. These findings suggest the potential of FBXW7 as a novel therapeutic target.
Please click "Read More" for more information.
Stay tuned for news about S-BIO
We will exhibit at the 3rd Academic Symposium of the MPS Practical Application Promotion Council
The 3rd Academic Symposium of the MPS Practical Application Promotion Council and the MPS Hands-On Seminar (co-hosted by CSAHi) will be held on January 26, 2026, at Tower Hall Funabori.This symposium will discuss the forefront of efforts toward the implementation of MPS by pharmaceutical companies and regulatory authorities.Our company will showcase and provide a hands-on demonstration of the on-chip multi-organ MPS "BioStallar® Plate," scheduled for release in January 2026. We look forward to welcoming you to the event.
☆ONE POINT S-BIO☆
Stemfull® is coated with a unique superhydrophilic polymer on the surface of the equipment, which suppresses cell adhesion and contributes to improved recovery rates. In single-cell recovery experiments of small intestinal organoids, Stemfull® demonstrated improved recovery rates compared to general centrifuge tubes.
I’m Takai from the S-Bio Division.
As the year-end approaches, the cold is becoming more intense, and the appeal of warm dishes increases all at once. Steaming soups, stews, and hot pots-the rising steam alone spreads happiness.
Taking a bite while warming your chilled hands on the bowl offers a unique deliciousness that other seasons can't match. No matter how cold it gets outside, the warmth of the dining table fills not just the body but also the heart.
It's a joy that can only be experienced during the cold winter. For me, the moment of heating up pre-prepared soup right after coming home is my little moment of comfort.
We also share information on social media.
This email is sent to customers who exchange business cards at exhibitions, etc. We use cookies, web beacons, and access logs on our website and in emails sent from us to analyze usage, conduct marketing and sales activities, and respond to inquiries.
Issued by: S-BIO Business Division,
Sumitomo Bakelite Co., Ltd.
Inquiry about S-BIO： Sumitomo Bakelite Co., Ltd. (sumibe.co.jp)
2-5-8 Higashi-Shinagawa, Shinagawa-ku,
Tokyo, 140 0002, Japan
