News from the S-BIO Business Division,
Sumitomo Bakelite Co., Ltd.

Desmoplasia in breast cancer is characterized by aberrant extracellular matrix (ECM) and vasculature, which lead to impaired drug delivery within the tumor microenvironment and posing challenges for personalized treatments. Current models fail to fully replicate this complexity, highlighting the need for the development of new therapeutic approaches.

This time, we introduce the paper "Personalized Vascularized Models of Breast Cancer Desmoplasia Reveal Biomechanical Determinants of Drug Delivery to the Tumor," published in Advanced Science (Wiley). In this study, tumoroids of breast cancer cell lines and patient-derived breast cancer cells were formed using the PrimeSurface^™ 96M plate and cultured in micro physiological system (MPS) containing microvascular networks (MVNs) to replicate desmoplastic stroma and vascular dysfunction.

The research revealed that stromal hyaluronic acid deposition, vascular permeability, and interstitial fluid pressure vary among cell lines, and that interleukin-8 is involved in vascular dysfunction. This MPS model can be personalized with patient-derived cells and is expected to contribute to the assessment of the tumor microenvironment and the discovery of novel therapies.

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We exhibited at the MPS World Summit 2025

Our company participated in the MPS World Summit 2025, held at Tour & Taxis in Brussels from June 9 to June 13. This summit has been gaining momentum year after year, and this year it brought together 1,485 participants from 44 countries and 124 sponsors and exhibiting companies.

A large number of visitors stopped by our booth, showing particularly high interest in our on-chip pump-type multi-organ MPS, "BioStellar^™ Plate," and our new product, "Sumilon^™ Companion Plate for Cell Culture Insert." Additionally, during the poster session, our researcher presented the result of collaborative research which had been conducted using BioStellar^™ Plate in partnership with the University of Tokyo, Kanazawa University, and Tokai University.

This presentation drew significant attention followed by vibrant discussion with audience, leading to a highly productive experience for ourselves.

Moving forward, our company will continue to deliver innovative products and services that contribute to the health of people worldwide.

This is Shin Saito from the Marketing and Sales Department of the S-Bio Division.

Everyone, it's now June and the rainy season has begun in Japan. It seems this year's rainy season will end early, leading to a very hot summer.

According to the Japan Meteorological Association, this is due to the "La Nina phenomenon," where water temperatures along the South American coast of the Pacific Ocean are lower than usual. It's hard to imagine that such distant changes can affect life here in Japan.

As we live within the Earth's vast ecosystem, what we can do is to stay healthy and stress-free.

Personally, I'm looking forward to beer gardens. How about you all?